The 2018 OMERACT Synovial Tissue Biopsy Special Interest Group Report on Standardization of Synovial Biopsy Analysis

J Rheumatol. 2019 Oct;46(10):1365-1368. doi: 10.3899/jrheum.181062. Epub 2019 Jan 15.


Objective: The Outcome Measures in Rheumatology (OMERACT) synovial tissue biopsy (STB) working group initiated an international effort to standardize STB analyses, define consensual items to inform treatment choices, and predict responses in rheumatoid arthritis (RA).

Methods: (1) A Delphi survey to determine items for STB analyses. (2) A multicenter retrospective study of STB data in patients with RA posttreatment with biological disease-modifying antirheumatic drugs.

Results: The Delphi survey identified 18 STB analyses items. Consensus on histological markers was achieved in the OMERACT 2018 SIG.

Conclusion: Six markers were identified for examination in a multicenter study designed to define an OMERACT-endorsed set of STB markers to predict responses to treatment.


Publication types

  • Multicenter Study

MeSH terms

  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Biological Products / therapeutic use*
  • Biomarkers
  • Biopsy / standards
  • Consensus
  • Delphi Technique
  • Humans
  • Outcome Assessment, Health Care / methods*
  • Public Opinion
  • Retrospective Studies
  • Rheumatology / methods*
  • Surveys and Questionnaires
  • Synovial Membrane / pathology*
  • Treatment Outcome


  • Antirheumatic Agents
  • Biological Products
  • Biomarkers