The 2018 OMERACT Synovial Tissue Biopsy Special Interest Group Report on Standardization of Synovial Biopsy Analysis

Mihir D Wechalekar; Aurélie Najm; Douglas J Veale; Vibeke Strand

doi:10.3899/jrheum.181062

The 2018 OMERACT Synovial Tissue Biopsy Special Interest Group Report on Standardization of Synovial Biopsy Analysis

J Rheumatol. 2019 Oct;46(10):1365-1368. doi: 10.3899/jrheum.181062. Epub 2019 Jan 15.

Authors

Mihir D Wechalekar^{1

2}, Aurélie Najm^{1

2}, Douglas J Veale^{3

4}, Vibeke Strand^{1

2}

Affiliations

¹ From the Rheumatology Unit, Flinders Medical Centre, Bedford Park and College of Medicine and Public Health, Flinders University, Adelaide, Australia; Rheumatology Department, Centre Hospitalier Universitaire (CHU) de Nantes, and INSERM UMR 1238, Faculty of Biology of Nantes, Nantes, France; The Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital and Dublin Academic Medical Centre, University College Dublin, Elm Park, Dublin, Ireland; Division of Immunology and Rheumatology, Stanford University, Palo Alto, California, USA.
² M.D. Wechalekar, PhD, Rheumatologist, Flinders Medical Centre and Senior Lecturer, Flinders University; A. Najm, MD, Rheumatology Department, CHU de Nantes, and INSERM UMR 1238, Faculty of Biology of Nantes; D.J. Veale, PhD, Director of Translational Research, Dublin Academic Medical Centre, Adjunct Professor of Medicine, University College Dublin, Fellow of The Conway Institute of Biomedical and Biomolecular Research, and Consultant Rheumatologist, St. Vincent's University Hospital; V. Strand, MD, Biopharmaceutical Consultant.
³ From the Rheumatology Unit, Flinders Medical Centre, Bedford Park and College of Medicine and Public Health, Flinders University, Adelaide, Australia; Rheumatology Department, Centre Hospitalier Universitaire (CHU) de Nantes, and INSERM UMR 1238, Faculty of Biology of Nantes, Nantes, France; The Centre for Arthritis and Rheumatic Diseases, St. Vincent's University Hospital and Dublin Academic Medical Centre, University College Dublin, Elm Park, Dublin, Ireland; Division of Immunology and Rheumatology, Stanford University, Palo Alto, California, USA. douglas.veale@ucd.ie.
⁴ M.D. Wechalekar, PhD, Rheumatologist, Flinders Medical Centre and Senior Lecturer, Flinders University; A. Najm, MD, Rheumatology Department, CHU de Nantes, and INSERM UMR 1238, Faculty of Biology of Nantes; D.J. Veale, PhD, Director of Translational Research, Dublin Academic Medical Centre, Adjunct Professor of Medicine, University College Dublin, Fellow of The Conway Institute of Biomedical and Biomolecular Research, and Consultant Rheumatologist, St. Vincent's University Hospital; V. Strand, MD, Biopharmaceutical Consultant. douglas.veale@ucd.ie.

PMID: 30647173
DOI: 10.3899/jrheum.181062

Abstract

Objective: The Outcome Measures in Rheumatology (OMERACT) synovial tissue biopsy (STB) working group initiated an international effort to standardize STB analyses, define consensual items to inform treatment choices, and predict responses in rheumatoid arthritis (RA).

Methods: (1) A Delphi survey to determine items for STB analyses. (2) A multicenter retrospective study of STB data in patients with RA posttreatment with biological disease-modifying antirheumatic drugs.

Results: The Delphi survey identified 18 STB analyses items. Consensus on histological markers was achieved in the OMERACT 2018 SIG.

Conclusion: Six markers were identified for examination in a multicenter study designed to define an OMERACT-endorsed set of STB markers to predict responses to treatment.

Keywords: OMERACT; SYNOVIUM.

Publication types

Multicenter Study

MeSH terms

Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / diagnosis*
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / pathology
Biological Products / therapeutic use*
Biomarkers
Biopsy / standards
Consensus
Delphi Technique
Humans
Outcome Assessment, Health Care / methods*
Public Opinion
Retrospective Studies
Rheumatology / methods*
Surveys and Questionnaires
Synovial Membrane / pathology*
Treatment Outcome

Substances

Antirheumatic Agents
Biological Products
Biomarkers