Electrocatalytic Tandem Synthesis of 1,3-Disubstituted Imidazo[1,5- a]quinolines via Sequential Dual Oxidative C(sp3)-H Amination in Aqueous Medium

Peng Qian; Zicong Yan; Zhenghong Zhou; Kangfei Hu; Jiawei Wang; Zhibin Li; Zhenggen Zha; Zhiyong Wang

doi:10.1021/acs.joc.8b03014

Electrocatalytic Tandem Synthesis of 1,3-Disubstituted Imidazo[1,5- a]quinolines via Sequential Dual Oxidative C(sp3)-H Amination in Aqueous Medium

J Org Chem. 2019 Mar 15;84(6):3148-3157. doi: 10.1021/acs.joc.8b03014. Epub 2019 Feb 1.

Authors

Peng Qian¹, Zicong Yan¹, Zhenghong Zhou¹, Kangfei Hu¹, Jiawei Wang¹, Zhibin Li¹, Zhenggen Zha¹, Zhiyong Wang¹

Affiliation

¹ Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science , University of Science and Technology of China , Hefei , Anhui 230026 , P. R. China.

PMID: 30648866
DOI: 10.1021/acs.joc.8b03014

Abstract

An NH₄I-mediated tandem electrosynthesis of 1,3-disubstituted imidazo[1,5- a]quinolines was developed from readily available starting materials in aqueous medium, affording a variety of 1,3-disubstituted imidazo[1,5- a]quinolines with good to excellent yields.