Serotonergic Axons as 3D-Walks

ACS Chem Neurosci. 2019 Jul 17;10(7):3064-3067. doi: 10.1021/acschemneuro.8b00667. Epub 2019 Jan 16.


Experimental and theoretical research suggests that serotonergic axons (fibers) can be modeled as random walks or stochastic processes. This rigorous approach can support descriptive methods and dynamic control of the ascending reticular activating system, at the level of individual fiber trajectories.

Keywords: 5-Hydroxytryptamine; fibers; fractional Brownian motion; random walk; stochastic process; von Mises-Fisher distribution.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Axons / physiology*
  • Models, Biological*
  • Serotonergic Neurons / physiology*
  • Stochastic Processes