Signet ring cell features with peritoneal carcinomatosis in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are associated with poor overall survival

J Surg Oncol. 2019 May;119(6):758-765. doi: 10.1002/jso.25379. Epub 2019 Jan 16.


Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is effective in select patients with peritoneal carcinomatosis (PC). Signet ring cell (SRC) pathology is associated with poor prognosis. The role of CRS/HIPEC in this population is unclear.

Methods: Patients diagnosed with PC due to appendiceal (AC), colorectal (CRC), and gastric cancer (GC) undergoing CRS/HIPEC 2007-2016 were included.

Results: A total of 268 patients were referred for CRS/HIPEC. Of the 204 patients who underwent complete CRS/HIPEC, 101 (49.5%) had AC, 85 (41.7%) CRC, and 18 (8.8%) GC. Patients with GC had higher rates of SRC pathology than AC and CRC: 12 (66.7%) vs 16 (15.8%) and 10 (11.7%). The 3-year survival rate after CRS/HIPEC was 5.7% for the SRC group and 66.1% for the non-SRC group (P < 0.001). This was true for both AC and CRC subgroups (P < 0.001 for both). Overall, patients with SRC were more likely to have a peritoneal carcinomatosis index (PCI) score > 15 (P = 0.046). Upon multivariate analysis of the SRC population, PCI > 20 (P = 0.007) and GC (P = 0.008) were found to be independent predictors of poor overall survival.

Conclusions: Performing CRS/HIPEC for PC from gastrointestinal malignancies presenting SRC features is recommended on patients with select diseases of appendiceal and colorectal origins.

Keywords: appendiceal carcinoma; colorectal carcinoma; cytoreductive surgery and hyperthermic intraperitoneal chemotherapy; gastric carcinoma; signet ring cell.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Signet Ring Cell / mortality
  • Carcinoma, Signet Ring Cell / pathology*
  • Carcinoma, Signet Ring Cell / therapy
  • Cytoreduction Surgical Procedures*
  • Female
  • Gastrointestinal Neoplasms / mortality
  • Gastrointestinal Neoplasms / pathology
  • Humans
  • Hyperthermia, Induced*
  • Male
  • Middle Aged
  • New York / epidemiology
  • Peritoneal Neoplasms / mortality*
  • Peritoneal Neoplasms / pathology*
  • Peritoneal Neoplasms / therapy
  • Prognosis
  • Retrospective Studies