Abstract
In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.
Copyright © 2018. Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Antiviral Agents*
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Apoptosis
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Carboxy-Lyases
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Humans
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Necrosis
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Neurons
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Nucleotides
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Proteins
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Receptor-Interacting Protein Serine-Threonine Kinases
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Zika Virus Infection*
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Zika Virus*
Substances
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Antiviral Agents
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Nucleotides
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Proteins
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RIPK3 protein, human
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Receptor-Interacting Protein Serine-Threonine Kinases
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ACOD1 protein, human
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Carboxy-Lyases