Blunted emotion-modulated startle reflex in anorexia nervosa

Int J Eat Disord. 2019 Mar;52(3):270-277. doi: 10.1002/eat.23022. Epub 2019 Jan 17.

Abstract

Objective: Patients with anorexia nervosa (AN) often show difficulties in the perception, expression, and regulation of emotions and a strong avoidance of aversive feelings. According to psychobiological models, dietary restraint and accompanying weight loss may serve as a maladaptive mechanism of emotion regulation by attenuating aversive emotional states in AN, thereby contributing to the maintenance of the disorder.

Method: Twenty-seven women with AN and 26 age-matched healthy women were shown short film-clips to elicit fear, sadness, amusement, and neutral emotional states. Eyeblink startle response was measured by electromyography in reaction to startle-eliciting acoustic stimuli presented 12 times binaurally during each film-clip.

Results: As compared to healthy controls, patients with AN showed a blunted startle response to the fear- but not to the sadness-eliciting stimulus.

Discussion: The findings support the assumption that underweight is associated with attenuated emotional reactivity to fear-eliciting material in AN. This is in line with the hypothesis that starvation and low body weight constitute a maladaptive mechanism of emotion regulation in AN, contributing to the maintenance of the disorder.

Keywords: eating disorders; emotion; emotional reactivity; eyeblink reflex; startle modulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anorexia Nervosa / psychology*
  • Emotions / physiology*
  • Female
  • Humans
  • Male
  • Reflex, Startle / physiology*
  • Young Adult