De novo formation and epigenetic maintenance of centromere chromatin

Curr Opin Cell Biol. 2019 Jun;58:15-25. doi: 10.1016/ Epub 2019 Jan 15.


Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Centromere / chemistry*
  • Centromere / metabolism
  • Chromatin / chemistry*
  • Chromatin / metabolism
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosome Segregation
  • Epigenesis, Genetic
  • Heterochromatin
  • Humans
  • Kinetochores / chemistry
  • Kinetochores / metabolism


  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Heterochromatin