Infertility is known to decrease quality of life among adults. In some cases, infertility is caused by medical conditions and/or treatments prescribed in childhood, and using methods to protect or preserve fertility may expand future reproductive possibilities. Structured programs to offer counseling about infertility risk and fertility preservation options are essential in the care of pediatric patients facing fertility-threatening conditions or treatments, yet multiple barriers to program development exist. This report was developed from the institutional experiences of members of the Pediatric Initiative Network of the Oncofertility Consortium, with the intent of providing guidance for health care providers aiming to establish programs at institutions lacking pediatric fertility preservation services. The mechanics of building a fertility preservation program are discussed, including essential team members, target populations, fertility preservation options (both established and experimental), survivorship issues, research opportunities, and ethical considerations. Common barriers to program development and utilization, including low referral rates and financial concerns, are also discussed, and recommendations made for overcoming such barriers.
Keywords: Adolescent; Child; Fertility preservation; Program development; Tissue preservation.
Copyright © 2018 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Dr. Pavone serves on the Ferring advisory board. All other authors have no conflicts of interest.
Utilizing the Experience of Consumers in Consultation to Develop the Australasian Oncofertility Consortium Charter.J Adolesc Young Adult Oncol. 2016 Sep;5(3):232-9. doi: 10.1089/jayao.2015.0056. Epub 2016 Mar 16. J Adolesc Young Adult Oncol. 2016. PMID: 26981709
Fertility Preservation for Pediatric Patients: Current State and Future Possibilities.J Urol. 2017 Jul;198(1):186-194. doi: 10.1016/j.juro.2016.09.159. Epub 2017 Feb 9. J Urol. 2017. PMID: 28189577 Review.
Effect of a formal oncofertility program on fertility preservation rates-first year experience.Transl Androl Urol. 2018 Jul;7(Suppl 3):S271-S275. doi: 10.21037/tau.2018.04.24. Transl Androl Urol. 2018. PMID: 30159232 Free PMC article.
A Study Protocol for the Australasian Oncofertility Registry: Monitoring Referral Patterns and the Uptake, Quality, and Complications of Fertility Preservation Strategies in Australia and New Zealand.J Adolesc Young Adult Oncol. 2016 Sep;5(3):215-25. doi: 10.1089/jayao.2015.0062. Epub 2016 Mar 16. J Adolesc Young Adult Oncol. 2016. PMID: 26981848 Review.
Fertility counseling and preservation: considerations for the pediatric endocrinologist.Transl Pediatr. 2017 Oct;6(4):313-322. doi: 10.21037/tp.2017.07.02. Transl Pediatr. 2017. PMID: 29184812 Free PMC article. Review.
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