Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report

Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2):a003434. doi: 10.1101/mcs.a003434. Print 2019 Apr.


Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease.

Keywords: ovarian neoplasm.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Granulosa Cell Tumor / drug therapy*
  • Humans
  • Imatinib Mesylate / administration & dosage*
  • Imatinib Mesylate / therapeutic use
  • Neoplasm Recurrence, Local / drug therapy*
  • Precision Medicine
  • Treatment Outcome


  • Imatinib Mesylate

Supplementary concepts

  • Granulosa cell tumor of the ovary