Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 86 (8), 717-724

Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach

Affiliations

Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach

H Simon Schaaf. Indian J Pediatr.

Abstract

Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only <5% of children with MDR-TB are currently diagnosed and appropriately treated. Diagnosing children with MDR-TB and getting them on to correct treatment regimens should now be our main focus.

Keywords: Children. Diagnosis; Management; Multidrug-resistant; Tuberculosis.

Similar articles

See all similar articles

Cited by 1 article

  • Advances in Tuberculosis: Therapeutics.
    Singh V, Kabra SK. Singh V, et al. Indian J Pediatr. 2019 Aug;86(8):700-702. doi: 10.1007/s12098-019-03005-3. Epub 2019 Jun 18. Indian J Pediatr. 2019. PMID: 31209764 No abstract available.

References

    1. Lancet Infect Dis. 2016 Oct;16(10):1193-1201 - PubMed

References

    1. Clin Infect Dis. 2014 Feb;58(3):381-91 - PubMed

References

    1. J Infect. 2013 Apr;66(4):320-9 - PubMed

References

    1. Lancet Glob Health. 2017 Sep;5(9):e898-e906 - PubMed

References

    1. Pediatr Infect Dis J. 2000 Aug;19(8):695-9 - PubMed

References

    1. Pediatr Infect Dis J. 2018 Dec;37(12):1199-1203 - PubMed

References

    1. Int J Tuberc Lung Dis. 2015 Jun;19(6):625 - PubMed

References

    1. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5976-85 - PubMed

References

    1. Clin Infect Dis. 2019 Apr 24;68(9):1522-1529 - PubMed

References

    1. Pediatr Infect Dis J. 2012 Apr;31(4):347-52 - PubMed

References

    1. Clin Infect Dis. 2014 Feb;58(3):392-5 - PubMed

References

    1. BMC Public Health. 2018 Mar 23;18(1):397 - PubMed

References

    1. Expert Opin Drug Saf. 2016 Oct;15(10):1369-81 - PubMed

References

    1. Bull World Health Organ. 2018 Oct 1;96(10):667-667A - PubMed

References

    1. Eur Respir J. 2012 Nov;40(5):1277-86 - PubMed

References

    1. Lancet Infect Dis. 2012 Jun;12(6):449-56 - PubMed

References

    1. Am J Respir Crit Care Med. 2012 Nov 15;186(10):953-64 - PubMed

References

    1. Int J Tuberc Lung Dis. 2000 Dec;4(12):1149-55 - PubMed

References

    1. PLoS Med. 2018 Jul 11;15(7):e1002591 - PubMed

References

    1. Lancet Respir Med. 2018 Sep;6(9):662-664 - PubMed

References

    1. J Antimicrob Chemother. 2015 Apr;70(4):1198-202 - PubMed

References

    1. N Engl J Med. 2018 Oct 11;379(15):1403-1415 - PubMed

References

    1. Indian J Radiol Imaging. 2009 Oct-Dec;19(4):256-65 - PubMed

References

    1. Am J Public Health. 2009 Aug;99(8):1486-90 - PubMed

References

    1. Br J Clin Pharmacol. 2018 Jun 27;: - PubMed

References

    1. Expert Rev Clin Pharmacol. 2018 Mar;11(3):233-244 - PubMed

References

    1. Thorax. 2014 May;69(5):458-64 - PubMed

References

    1. PLoS One. 2014 Aug 20;9(8):e105346 - PubMed

References

    1. Int J Tuberc Lung Dis. 2018 May 1;22(5):3-6 - PubMed

References

    1. Int J Antimicrob Agents. 2017 Feb;49(2):212-217 - PubMed

References

    1. J Clin Microbiol. 2015 Sep;53(9):2961-9 - PubMed

References

    1. PLoS One. 2015 Mar 04;10(3):e0117421 - PubMed

LinkOut - more resources

Feedback