Gut microbiota in neurodegenerative disorders

Suparna Roy Sarkar; Sugato Banerjee

doi:10.1016/j.jneuroim.2019.01.004

Gut microbiota in neurodegenerative disorders

J Neuroimmunol. 2019 Mar 15:328:98-104. doi: 10.1016/j.jneuroim.2019.01.004. Epub 2019 Jan 9.

Authors

Suparna Roy Sarkar¹, Sugato Banerjee²

Affiliations

¹ Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.
² Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India. Electronic address: sbanerjee@bitmesra.ac.in.

PMID: 30658292
DOI: 10.1016/j.jneuroim.2019.01.004

Abstract

Gut dysbiosis, a primary factor behind various gastrointestinal disorders may also augment lipopolysaccharides, pro-inflammatory cytokines, T helper cells and monocytes causing increased intestinal and BBB permeability via microbiota-gut-brain axis. Consequentially, accumulation of misfolded proteins, axonal damage and neuronal demyelination sets in, thus facilitating the pathogenesis of neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis. Studies revealed that intake of probiotics may help in the integrity of intestinal and BBB thus ameliorating the above neurodegenerative disorders. This review summarizes the current understanding of the role of gut microbiota in neurodegenerative disorders and possible intervention strategies.

Publication types

Review

MeSH terms

Animals
Gastrointestinal Microbiome / physiology*
Humans
Neurodegenerative Diseases / microbiology*