Ginger: A Novel Strategy to Battle Cancer through Modulating Cell Signalling Pathways: A Review

Curr Pharm Biotechnol. 2019;20(1):5-16. doi: 10.2174/1389201020666190119142331.

Abstract

Numerous studies have been performed in understanding the development of cancer. Though, the mechanism of action of genes in the development of cancer remains to be explained. The current mode of treatment of cancer shows adverse effects on normal cells and also alter the cell signalling pathways. However, ginger and its active compound have fascinated research based on animal model and laboratories during the past decade due to its potentiality in killing cancer cells. Ginger is a mixture of various compounds including gingerol, paradol, zingiberene and shogaol and such compounds are the main players in diseases management. Most of the health-promoting effects of ginger and its active compound can be attributed due to its antioxidant and anti-tumour activity. Besides, the active compound of ginger has proven its role in cancer management through its modulatory effect on tumour suppressor genes, cell cycle, apoptosis, transcription factors, angiogenesis and growth factor. In this review, the role of ginger and its active compound in the inhibition of cancer growth through modulating cell signalling pathways will be reviewed and discussed.

Keywords: Ginger; antioxidant activity; antitumor activity; cell signalling pathway; gingerol; shogaol..

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Apoptosis / drug effects
  • Apoptosis / physiology
  • Catechols / isolation & purification
  • Catechols / pharmacology
  • Catechols / therapeutic use
  • Cell Cycle / drug effects*
  • Cell Cycle / physiology
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology
  • Fatty Alcohols / therapeutic use
  • Ginger*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology

Substances

  • Antioxidants
  • Catechols
  • Fatty Alcohols
  • Plant Extracts
  • shogaol
  • gingerol