Research Progress of Glycyrrhizic Acid on Antiviral Activity

Mini Rev Med Chem. 2019;19(10):826-832. doi: 10.2174/1389557519666190119111125.


Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.

Keywords: Glycyrrhizic acid; HIV; antiviral effects; hepatitis virus; herpes virus; influenza virus..

Publication types

  • Review

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Glycyrrhiza / chemistry
  • Glycyrrhizic Acid / chemistry
  • Glycyrrhizic Acid / isolation & purification
  • Glycyrrhizic Acid / pharmacology*
  • HIV / drug effects*
  • Hepacivirus / drug effects*
  • Hepatitis B Surface Antigens / metabolism
  • Hepatitis B virus / drug effects*
  • Humans


  • Antiviral Agents
  • Hepatitis B Surface Antigens
  • Glycyrrhizic Acid