Dependence of the MR signal on the magnetic susceptibility of blood studied with models based on real microvascular networks

Magn Reson Med. 2019 Jun;81(6):3865-3874. doi: 10.1002/mrm.27660. Epub 2019 Jan 18.

Abstract

Purpose: The primary goal of this study was to estimate the value of β , the exponent in the power law relating changes of the transverse relaxation rate and intra-extravascular local magnetic susceptibility differences as Δ R 2 ( Δ χ ) β . The secondary objective was to evaluate any differences that might exist in the value of β obtained using a deoxyhemoglobin-weighted Δ χ distribution versus a constant Δ χ distribution assumed in earlier computations. The third objective was to estimate the value of β that is relevant for methods based on susceptibility contrast agents with a concentration of Δ χ higher than that used for BOLD fMRI calculations.

Methods: Our recently developed model of real microvascular anatomical networks is used to extend the original simplified Monte-Carlo simulations to compute β from the first principles.

Results: Our results show that β = 1 for most BOLD fMRI measurements of real vascular networks, as opposed to earlier predictions of β = 1 .5 using uniform Δ χ distributions. For perfusion or fMRI methods based on contrast agents, which generate larger values for Δ χ , β = 1 for B 0 9.4 T, whereas at 14 T β can drop below 1 and the variation across subjects is large, indicating that a lower concentration of contrast agent with a lower value of Δ χ is desired for experiments at high B0 .

Conclusion: These results improve our understanding of the relationship between R2 * and the underlying microvascular properties. The findings will help to infer the cerebral metabolic rate of oxygen and cerebral blood volume from BOLD and perfusion MRI, respectively.

Keywords: BOLD fMRI; contrast agents; microvascular network; modeling; perfusion MRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / diagnostic imaging
  • Contrast Media
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Inbred C57BL
  • Microvessels / diagnostic imaging*
  • Models, Cardiovascular
  • Monte Carlo Method
  • Perfusion Imaging / methods*

Substances

  • Contrast Media