The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior

Neurosci Biobehav Rev. 2019 Feb;97:96-111. doi: 10.1016/j.neubiorev.2018.07.018. Epub 2019 Jan 16.


Following the Research Domain Criteria (RDoC) concept, major brain circuits are conserved in evolution and malfunctioning of a brain circuit will lead to specific behavioral symptoms. Reverse translation of patient-based findings from Alzheimer's disease (AD), schizophrenia (SZ) and major depression (MD) patients to preclinical models accordingly can be a starting point for developing a deeper understanding of the functional circuit biology and contribute to the validation of new hypotheses for therapeutic intervention in patients. In the context of the EU funded PRISM project, a preclinical test battery of tasks has been selected and aligned with the clinical test battery. It allows for assessment of social functioning, sensory processing, attention and working memory and is designed for validation of biological substrates from human molecular landscaping of social withdrawal. This review will broadly summarize the available literature on tasks for studying social behavior in rodents and outline the development of a preclinical test battery for the PRISM project by reverse translation.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / psychology
  • Animals
  • Behavior, Animal
  • Brain / physiopathology*
  • Depressive Disorder, Major / physiopathology
  • Depressive Disorder, Major / psychology
  • Disease Models, Animal*
  • Humans
  • Interpersonal Relations*
  • Mental Disorders / physiopathology*
  • Mental Disorders / psychology*
  • Research Design
  • Schizophrenia / physiopathology
  • Schizophrenic Psychology
  • Social Isolation*