Pancreatic B-cell function in relation to diabetic retinopathy in Asian Indian NIDDM patients

Acta Diabetol Lat. Apr-Jun 1988;25(2):95-100. doi: 10.1007/BF02581372.


Pancreatic B-cell function in relation to diabetic retinopathy was studied in 195 NIDDM patients with long-standing diabetes. Background diabetic retinopathy (BDR) was present in 95 (48.7%) and proliferative retinopathy (PDR) in 17 (8.7%) of the subjects. There was no significant difference between the BDR, PDR, and non-retinopathy groups with respect to age, age at diagnosis of diabetes and HbA1 values. Mean duration of diabetes was higher in the PDR group (p less than 0.05). Serum C-peptide values showed no correlation with the presence of retinopathy or with the duration of diabetes. The C-peptide values were widely scattered in patients with BDR and PDR showing no association between pancreatic B-cell reserve and occurrence or severity of retinopathy in NIDDM patients. Thus, decreased pancreatic B-cell reserve does not appear to be a risk factor for diabetic retinopathy in NIDDM patients.

MeSH terms

  • Blood Glucose / analysis
  • C-Peptide / blood*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetic Retinopathy / physiopathology*
  • Glycated Hemoglobin A / analysis
  • Humans
  • India
  • Islets of Langerhans / metabolism*
  • Triglycerides / blood
  • Whites


  • Blood Glucose
  • C-Peptide
  • Glycated Hemoglobin A
  • Triglycerides