Congenital Large Cutaneous Hemangioma With Arteriovenous and Arterioarterial Malformations: A Novel Association

Fetal Pediatr Pathol. 2019 Feb;38(1):85-90. doi: 10.1080/15513815.2018.1547337. Epub 2019 Jan 19.


Background: Congenital cutaneous hemangioma is a benign vascular lesion that is a leading cause of severe hemodynamic compromise in a fetus when it is of significant size and especially in association with arteriovenous malformation.

Case report: A large cutaneous hemangioma involving the right arm of a 32-week-old male fetus was complicated by fetal hypotrophy, hydrops fetalis and neonatal death. Axillary arteriovenous fistulas and bilateral arterial carotid-subclavian anastomosis were demonstrated at autopsy. Microscopically, the main tumor was a mixed capillary-cavernous hemangioma with vascular channels lined by CD31-positive and GLUT1/Ki-67-negative endothelial cells.

Conclusion: Congenital hemangioma can be associated with vascular malformations, and that associations with other vascular malformations may increase the morbidity/mortality.

Keywords: Congenital hemangioma; congestive heart failure; hydrops fetalis; vascular malformation.

Publication types

  • Case Reports

MeSH terms

  • Hemangioma / complications*
  • Hemangioma / congenital*
  • Humans
  • Infant, Newborn
  • Male
  • Perinatal Death
  • Skin Neoplasms / complications*
  • Skin Neoplasms / congenital*
  • Vascular Malformations / complications*