Joint replacement in X-linked hypophosphatemia

Emily S Mills; Louis Iorio; Richard S Feinn; Kevin M Duignan; Carolyn M Macica

doi:10.1016/j.jor.2018.12.007

Joint replacement in X-linked hypophosphatemia

J Orthop. 2018 Dec 21;16(1):55-60. doi: 10.1016/j.jor.2018.12.007. eCollection 2019 Jan-Feb.

Authors

Emily S Mills¹, Louis Iorio¹, Richard S Feinn¹, Kevin M Duignan¹, Carolyn M Macica¹

Affiliation

¹ Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT, 06518, USA.

Abstract

X-linked hypophosphatemia (XLH) is associated with a pervasive, severe degenerative osteoarthritis. We conducted a retrospective chart review/patient survey using the Knee or Hip Osteoarthritis Outcome Score Physical Function Short Form. Fourteen total knee arthroplasties and 7 total hip arthroplasties among 11 patients were included. The mean KOOS-PS score was 31.4 ± 9.7 with a mean follow up of 6.9 years. Mean HOOS-PS score was 14.8 ± 12.9 at a mean follow up of 7.6 years. One knee failed due to aseptic loosening and one hip was revised due to polyethylene wear. In conclusion, total joint arthroplasty is beneficial in XLH.

Keywords: Hip arthroplasty; Knee arthroplasty; Knee or hip osteoarthritis outcome score physical function short form; Osteomalacia; Phosphate-wasting disorders; X-linked hypophosphatemia.