Systematic Review of Topical Hemostatic Agent Use in Minimally Invasive Gynecologic Surgery

JSLS. Oct-Dec 2018;22(4):e2018.00070. doi: 10.4293/JSLS.2018.00070.


Background and objectives: To perform a systematic review of articles evaluating hemostatic effectiveness and peri-operative outcomes when topical hemostatic agents (HA) are used in minimally invasive gynecologic surgeries (MIGS) for benign conditions.

Methods: Studies published through March 31, 2017 were retrieved through PubMed, EMBASE, Cochrane, and to identify all eligible studies. No studies were excluded based on publish date. All comparative studies or case series with >10 participants reporting use of at least one topical HA in MIGS for benign conditions were included as long as full-text articles were available and written in English. Studies were excluded if surgery was done for malignancy or completed via an open approach. Articles that included multiple surgical subspecialties were excluded if data related to MIGS was unable to be isolated. Evaluation for eligibility and data extraction was performed by three independent reviewers. Quality of evidence was also assessed by each reviewer.

Results: From 132 articles, a total of 8 studies were included in this systematic review. We found that use of fibrin sealant decreased time to hemostasis, postoperative hemoglobin drop, and estimated blood loss (EBL) compared with bipolar energy and reduced the overall operative time in laparoscopic myomectomy. When fibrin sealant use at time of myomectomy was compared to bipolar energy there was no significant difference in the rate of postoperative complications. Furthermore, there was less of a decrease in anti-Mullerian hormone (AMH) level when a thrombin-gelatin matrix was used compared to bipolar energy on ovarian tissue.

Conclusion: Application of topical HA in MIGS can reduce operative time, blood loss, and ameliorate damage to ovarian function. However, more data needs to be gathered for use of HA during different types of gynecologic procedures (adnexal surgery, myomectomy, and hysterectomy) to provide better quality evidence to guide their use.

Keywords: Gynecology; Hemostasis; Hemostatic Agents; Minimally Invasive Surgery; Topical Agents.

Publication types

  • Systematic Review

MeSH terms

  • Administration, Topical
  • Blood Loss, Surgical
  • Female
  • Fibrin Tissue Adhesive / therapeutic use*
  • Gynecologic Surgical Procedures*
  • Hemostatics / therapeutic use*
  • Humans
  • Minimally Invasive Surgical Procedures*
  • Operative Time


  • Fibrin Tissue Adhesive
  • Hemostatics