Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells

Jinping Liang; Jun Shi; Na Wang; Hui Zhao; Jianmin Sun

doi:10.7150/jca.27633

Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells

J Cancer. 2019 Jan 1;10(1):105-111. doi: 10.7150/jca.27633. eCollection 2019.

Authors

Jinping Liang^{1

2}, Jun Shi¹, Na Wang¹, Hui Zhao³, Jianmin Sun^{1

4}

Affiliations

¹ School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R.China.
² Ningxia Key laboratory of Clinical and Pathogenic Microbiology, The General Hospital of Ningxia Medical University, Yinchuan, China.
³ School of Biomedical Science, Faculty of Medicine, the Chinese University of Hong Kong.
⁴ Division of Translational Cancer Research, Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Abstract

Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

Keywords: PTPRE; cancer; signaling; tyrosine phosphatase.

Publication types

Review