Azole resistance of Malassezia pachydermatis causing treatment failure in a dog

Med Mycol Case Rep. 2018 Dec 21:23:58-61. doi: 10.1016/j.mmcr.2018.12.004. eCollection 2019 Mar.


A 5-year-old neutered female toy Poodle chronically treated with systemic and topical azoles to control recurrent Malassezia dermatitis/otitis was presented because of the loss of treatment efficacy. Minimum Inhibitory Concentrations (MICs) obtained in vitro for various azoles (especially itraconazole and ketoconazole) against Malassezia strains isolated from the dog were increased by several-fold compared with MICs obtained for control isolates. These results reinforced the assumption based on clinical observation, i.e. the development of azole resistance.

Keywords: Azoles; Dog; Malassezia pachydermatis; Resistance.

Publication types

  • Case Reports