Ribosomal DNA-connecting ribosome biogenesis and chromosome biology

Chromosome Res. 2019 Mar;27(1-2):1-3. doi: 10.1007/s10577-018-9601-4. Epub 2019 Jan 21.

Abstract

Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome. The locus can impact not only the translational capability of cells, but also genome organization, stability and integrity, providing a link between translation and chromosome biology.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Animals
  • Chromosomes / genetics*
  • Chromosomes / metabolism
  • DNA Replication
  • DNA, Ribosomal / genetics*
  • DNA, Ribosomal / metabolism
  • Gene Expression Regulation
  • Genome
  • Genomics* / methods
  • Humans
  • Ribosomes / chemistry
  • Ribosomes / genetics*
  • Ribosomes / metabolism*

Substances

  • DNA, Ribosomal