Association between Helicobacter pylori infection, eradication and diabetes mellitus

J Diabetes Investig. 2019 Sep;10(5):1341-1346. doi: 10.1111/jdi.13011. Epub 2019 Feb 12.


Aims/introduction: It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes.

Materials and methods: The present cross-sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as "never," "current" and "past." The association between H. pylori infection and diabetes was examined using logistic regression.

Results: Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the "never" group were 1.36 (95% confidence interval 1.10-1.67) for the "current" group and 0.92 (95% confidence interval 0.79-1.07) for the "past" group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication.

Conclusions: We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.

Keywords: Helicobacter pylori; Eradication; Inflammation.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Biomarkers
  • Cross-Sectional Studies
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus / prevention & control*
  • Female
  • Follow-Up Studies
  • Helicobacter Infections / complications
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / prevention & control*
  • Helicobacter pylori / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Risk Factors


  • Anti-Bacterial Agents
  • Biomarkers