Pretreatment Controlling Nutritional Status Score and Lactate Dehydrogenase as Predictive Markers of Survival in Patients with Malignant Peritoneal Mesothelioma

Nutr Cancer. Nov-Dec 2018;70(8):1264-1274. doi: 10.1080/01635581.2018.1560481. Epub 2019 Jan 20.

Abstract

Objective: To investigate the relationships between the Controlling Nutritional Status (CONUT) score and ascites fluid lactate dehydrogenase (LDH) level, and prognosis in patients with malignant peritoneal mesothelioma (MPeM).

Methods: A total of 125 patients with MPeM were selected for the study using a pathological screening method. Once the diagnosis is established, before the treatment their clinical characteristics and nutritional evaluations were recorded including CONUT score and ascites LDH level. The associations between CONUT, ascites LDH, and other clinicopathological features including body mass index, asbestos exposure, pathological type, and treatment method were analyzed. Prognostic parameters predicting overall survival (OS) were analyzed by Cox regression.

Results: High CONUT score, high ascites LDH level were positively associated with poor prognosis in patients with MPeM according to univariate analyses (P < 0.001, P < 0.001, respectively), and CONUT score and ascites LDH were independent predictors of a poor prognosis according to multivariate analysis. When the CONUT score is greater than 3 and the ascites LHD is greater than 474 IU/l, it indicates a poor prognosis.

Conclusions: CONUT score and ascites LDH are important factors influencing the prognosis of MPeM patients and should thus be considered in clinical applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asbestos / toxicity
  • Biomarkers, Tumor / blood
  • Female
  • Humans
  • L-Lactate Dehydrogenase / blood*
  • Male
  • Mesothelioma / drug therapy
  • Mesothelioma / mortality*
  • Mesothelioma / surgery
  • Middle Aged
  • Nutritional Status / physiology*
  • Peritoneal Neoplasms / drug therapy
  • Peritoneal Neoplasms / mortality*
  • Peritoneal Neoplasms / surgery
  • Prognosis
  • ROC Curve

Substances

  • Biomarkers, Tumor
  • Asbestos
  • L-Lactate Dehydrogenase