Angiotensin-Converting Enzyme Inhibitors Induce Cough

Turk Thorac J. 2019 Jan 1;20(1):36-42. doi: 10.5152/TurkThoracJ.2018.18014.


Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as hypertension, congestive heart failure, and myocardial infarction. Although these drugs are well tolerated, one out of five patients discontinues ACE-I due to drug side effects, mainly chronic cough. However, the pathogenesis of ACE-I-induced cough remains controversial and requires further study. In this review, the mechanisms that are suggested in ACE-I-induced cough pathophysiology will be discussed in detail in light of the current literature.

Publication types

  • Review