Transient receptor potential channels in cardiac health and disease

Nat Rev Cardiol. 2019 Jun;16(6):344-360. doi: 10.1038/s41569-018-0145-2.


Transient receptor potential (TRP) channels are nonselective cationic channels that are generally Ca2+ permeable and have a heterogeneous expression in the heart. In the myocardium, TRP channels participate in several physiological functions, such as modulation of action potential waveform, pacemaking, conduction, inotropy, lusitropy, Ca2+ and Mg2+ handling, store-operated Ca2+ entry, embryonic development, mitochondrial function and adaptive remodelling. Moreover, TRP channels are also involved in various pathological mechanisms, such as arrhythmias, ischaemia-reperfusion injuries, Ca2+-handling defects, fibrosis, maladaptive remodelling, inherited cardiopathies and cell death. In this Review, we present the current knowledge of the roles of TRP channels in different cardiac regions (sinus node, atria, ventricles and Purkinje fibres) and cells types (cardiomyocytes and fibroblasts) and discuss their contribution to pathophysiological mechanisms, which will help to identify the best candidates for new therapeutic targets among the cardiac TRP family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials
  • Animals
  • Cardiovascular Agents / therapeutic use
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism*
  • Heart Diseases / drug therapy
  • Heart Diseases / metabolism*
  • Heart Diseases / physiopathology
  • Humans
  • Molecular Targeted Therapy
  • Myocytes, Cardiac / drug effects
  • Myocytes, Cardiac / metabolism*
  • Purkinje Fibers / drug effects
  • Purkinje Fibers / metabolism*
  • Purkinje Fibers / physiopathology
  • Signal Transduction
  • Sinoatrial Node / drug effects
  • Sinoatrial Node / metabolism*
  • Sinoatrial Node / physiopathology
  • Transient Receptor Potential Channels / drug effects
  • Transient Receptor Potential Channels / metabolism*


  • Cardiovascular Agents
  • Transient Receptor Potential Channels