Acute silencing of hippocampal CA3 reveals a dominant role in place field responses

Nat Neurosci. 2019 Mar;22(3):337-342. doi: 10.1038/s41593-018-0321-z. Epub 2019 Jan 21.

Abstract

Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CA1 Region, Hippocampal / physiology*
  • CA3 Region, Hippocampal / physiology*
  • Male
  • Neural Pathways / physiology
  • Optogenetics
  • Place Cells / physiology*
  • Rats, Long-Evans