Dynamics of mRNA entry into stress granules

Nat Cell Biol. 2019 Feb;21(2):116-117. doi: 10.1038/s41556-019-0278-5.

Abstract

Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

Publication types

  • Comment

MeSH terms

  • Cytoplasmic Granules*
  • RNA, Messenger
  • Stress, Physiological*

Substances

  • RNA, Messenger