Management and treatment of glomerular diseases (part 2): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Kidney Int. 2019 Feb;95(2):281-295. doi: 10.1016/j.kint.2018.11.008.


In November 2017, the Kidney Disease: Improving Global Outcomes (KDIGO) initiative brought a diverse panel of experts in glomerular diseases together to discuss the 2012 KDIGO glomerulonephritis guideline in the context of new developments and insights that had occurred over the years since its publication. During this KDIGO Controversies Conference on Glomerular Diseases, the group examined data on disease pathogenesis, biomarkers, and treatments to identify areas of consensus and areas of controversy. This report summarizes the discussions on primary podocytopathies, lupus nephritis, anti-neutrophil cytoplasmic antibody-associated nephritis, complement-mediated kidney diseases, and monoclonal gammopathies of renal significance.

Keywords: C3 glomerulopathy; KDIGO; anti-neutrophil cytoplasmic antibody–associated vasculitis; focal and segmental glomerulosclerosis; lupus nephritis; membranoproliferative glomerulonephritis; minimal change disease; monoclonal gammopathies of renal significance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / complications
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / genetics
  • Biomarkers / analysis
  • Consensus Development Conferences as Topic
  • Disease Progression
  • Genetic Testing
  • Glomerular Filtration Rate
  • Glomerulonephritis / etiology
  • Glomerulonephritis / pathology
  • Glomerulonephritis / therapy*
  • Humans
  • Nephrology / methods
  • Nephrology / standards
  • Nephrosis, Lipoid / etiology
  • Nephrosis, Lipoid / pathology
  • Nephrosis, Lipoid / therapy*
  • Paraproteinemias / complications
  • Paraproteinemias / diagnosis
  • Paraproteinemias / genetics
  • Podocytes / immunology
  • Podocytes / pathology
  • Practice Guidelines as Topic*
  • Risk Factors
  • Treatment Outcome


  • Biomarkers