Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

Jonathan Downar

doi:10.1016/j.cub.2018.11.057

Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

Curr Biol. 2019 Jan 21;29(2):R59-R62. doi: 10.1016/j.cub.2018.11.057.

Author

Jonathan Downar¹

Affiliation

¹ Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Canada; Krembil Research Institute, University Health Network, Toronto, Canada; Centre for Mental Health, University Health Network, Toronto, Canada; MRI-Guided rTMS Clinic, Poul Hansen Centre for Depression, University Health Network, Toronto, Canada. Electronic address: jonathan.downar@uhn.ca.

PMID: 30668950
DOI: 10.1016/j.cub.2018.11.057

Abstract

Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies.

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MeSH terms

Depression*
Electric Stimulation
Humans
Magnetic Resonance Imaging*
Prefrontal Cortex
Reward