[Correlation analysis of eosinophils in peripheral blood and polyp tissues of patients with chronicrhinosinusitis with nasal polyps]

Z C Zhang; P Z Li; H Y Tang; L Cheng

doi:10.13201/j.issn.1001-1781.2019.01.004

[Correlation analysis of eosinophils in peripheral blood and polyp tissues of patients with chronicrhinosinusitis with nasal polyps]

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jan;33(1):14-16. doi: 10.13201/j.issn.1001-1781.2019.01.004.

[Article in Chinese]

Authors

Z C Zhang¹, P Z Li, H Y Tang, L Cheng

Affiliation

¹ Department of Otorhinolaryngology, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an,223300,China.

PMID: 30669192
DOI: 10.13201/j.issn.1001-1781.2019.01.004

Abstract

Objective:To explore the correlation between peripheral blood eosinophils and tissue eosinophils in patients with chronic rhinosinusitis with nasal polyps(CRSwNP) in different periods.Method:This trial was a prospective study involved 342 patients with CRSwNP who were treated by endoscopic sinus surgery in the Huai'an First People's Hospital, Nanjing Medical University in 2008, 2012 and 2016. Nasal polyp resection specimens were stained by HE.Tissue eosinophils were counted per high-power field, and peripheral blood eosinophils were collected from blood routine examination before operation.The relationship between peripheral blood eosinophils and tissue eosinophils were evaluated.Result:The correlation between peripheral blood eosinophils and tissue eosinophils was positive in nasal polyps in 2008,2012 and 2016(r= 0.275,0.435,0.505, respectively). AUC values were all greater than 0.7. Conclusion:There is a positive correlation between peripheral blood eosinophils and tissue eosinophils infiltration in patients with CRSwNP. Although the cutoff value is changing, peripheral blood eosinophils can be used as an indicator for predicting eosinophilic CRSwNP.

Keywords: eosinophils; nasal polyps; sinusitis.

Publication types

English Abstract