[A Meta-analysis of sublingual immunotherapy in the treatment of seasonal allergic rhinitis]

Abstract

Objective:To systematically evaluate the efficacy and adverse reactions of sublingual immunotherapy for patients with seasonal allergic rhinitis.Method:Literature databases including PubMed, Embase, Cochrane Library, Medline, CBM, Wanfang, CNKI. The time of literature search was limited from January of 2008 to December of 2017.The literature of randomized controlled trials of sublingual immunotherapy for seasonal allergic rhinitis was screened,the quality of the included literature was evaluated,data was extracted,and meta-analysis was performed using RevMan5.3 software.Result:A total of 10 articles were included. The results of meta-analysis showed that for seasonal allergic rhinitis sublingual immunotherapy compared with the control group can reduce symptom scores （SMD=-0.30, 95%CI［-0.39,-0.21］,P<0.000 01) and medication scores (SMD=-0.18, 95%CI［-0.29，-0.08］, P=0.000 8); sublingual immunotherapy for seasonal allergic rhinitis is not restricted by age in the relief of symptoms, and there is no age restriction on reduce medication requirements; sublingual immunotherapy had a higher incidence of adverse reactions than the control group, but it was mostly localized, such as oral pruritus, ear pruritus, throat irritation.Conclusion:Sublingual immunotherapy can alleviate the symptoms and reduce medication requirements in patients with seasonal allergic rhinitis. The adverse reactions are slightly controllable.

Keywords: Meta-analysis; randomized controlled trial; rhinitis,allergic; sublingual immunotherapy.