Wheat Albumin Increases the Ratio of Fat to Carbohydrate Oxidation during the Night in Healthy Participants: A Randomized Controlled Trial

Nutrients. 2019 Jan 18;11(1):197. doi: 10.3390/nu11010197.


Not only are energy expenditure (EE) and the respiratory quotient (RQ) parameters of the energy nutrient utilization and energy balance, they are also related to the development of obesity. In this study, post-meal night-time energy metabolism was investigated following the oral ingestion of wheat albumin (WA) with a late evening meal. A randomly assigned, double-blind, placebo-controlled crossover trial for a single oral ingestion in healthy participants was completed. The participants ingested the placebo (PL) or WA (1.5 g) containing tablets 3 minutes before the late evening meal at 22:00 hour, and energy metabolism was measured using a whole-room indirect calorie meter until wake-up. The participants were in bed from 00:00 hour until 06:30 hour. Twenty healthy participants completed the trial and were included in the analyses. Night-time RQ and carbohydrate oxidation were significantly lower following the WA treatment as compared with the PL treatment. Although the total EE was not significantly different between treatments, postprandial fat oxidation was significantly higher following the WA treatment as compared with the PL treatment. In conclusion, WA has the potential to shift the energy balance to a higher ratio of fat to carbohydrate oxidation during the night.

Keywords: energy expenditure; fat oxidation; human; respiratory quotient; wheat albumin.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Albumins / pharmacology*
  • Carbohydrate Metabolism
  • Dietary Carbohydrates / metabolism*
  • Dietary Fats / metabolism*
  • Double-Blind Method
  • Eating / physiology*
  • Energy Metabolism / drug effects*
  • Female
  • Humans
  • Lipid Metabolism
  • Male
  • Meals
  • Obesity / etiology
  • Oxidation-Reduction
  • Oxygen Consumption
  • Postprandial Period*
  • Respiration
  • Triticum / chemistry*


  • Albumins
  • Dietary Carbohydrates
  • Dietary Fats