The Many Faces of FKBP51

Biomolecules. 2019 Jan 21;9(1):35. doi: 10.3390/biom9010035.

Abstract

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51's physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.

Keywords: FK506; FKBP51; GR; Hsp90; NF-κB; SAFit; glucocorticoids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Glucocorticoids / chemistry
  • Glucocorticoids / metabolism
  • HSP90 Heat-Shock Proteins / chemistry
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Metabolic Diseases / metabolism
  • Metabolic Diseases / pathology
  • NF-kappa B / chemistry
  • NF-kappa B / metabolism
  • Proto-Oncogene Proteins c-akt / chemistry
  • Proto-Oncogene Proteins c-akt / metabolism
  • Receptors, Steroid / chemistry
  • Receptors, Steroid / metabolism
  • Stress Disorders, Post-Traumatic / metabolism
  • Stress Disorders, Post-Traumatic / pathology
  • Tacrolimus Binding Proteins / chemistry
  • Tacrolimus Binding Proteins / genetics
  • Tacrolimus Binding Proteins / metabolism*

Substances

  • Glucocorticoids
  • HSP90 Heat-Shock Proteins
  • NF-kappa B
  • Receptors, Steroid
  • Proto-Oncogene Proteins c-akt
  • Tacrolimus Binding Proteins
  • tacrolimus binding protein 5