Fueling Ketone Metabolism Quenches Salt-Induced Hypertension

David E Place; Thirumala-Devi Kanneganti

doi:10.1016/j.tem.2019.01.004

Fueling Ketone Metabolism Quenches Salt-Induced Hypertension

Trends Endocrinol Metab. 2019 Mar;30(3):145-147. doi: 10.1016/j.tem.2019.01.004. Epub 2019 Jan 19.

Authors

David E Place¹, Thirumala-Devi Kanneganti²

Affiliations

¹ Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
² Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: thirumala-devi.kanneganti@stjude.org.

PMID: 30670332
DOI: 10.1016/j.tem.2019.01.004

Abstract

Understanding the molecular mechanisms by which diet and exercise regulate disease has the potential to help identify new treatments. In their recent study, Chakraborty et al. (Cell Reports 2018;25:677-689) discovered that supplementation with a metabolic precursor produced β-hydroxybutyrate (BHB), counteracting the pathological effects of high-salt diet-induced hypertension, suggesting a new treatment modality.

Keywords: 1,3-butanediol; beta-hydroxybutyrate; hypertension; inflammasome; ketone; kidney disease.

Publication types

Review

MeSH terms

3-Hydroxybutyric Acid / therapeutic use*
Animals
Butylene Glycols / metabolism
Humans
Hypertension / chemically induced*
Hypertension / drug therapy*
Hypertension / metabolism
Ketone Bodies / metabolism*
Sodium Chloride / adverse effects

Substances

Butylene Glycols
Ketone Bodies
1,3-butylene glycol
Sodium Chloride
3-Hydroxybutyric Acid