PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae

Mol Gen Genet. 1988 Sep;214(1):162-4. doi: 10.1007/BF00340196.


The product of the PHO85 gene, which encodes one of the negative regulatory factors of the PHO system in Saccharomyces cerevisiae, shows significant amino acid sequence homology with the CDC28 protein kinase. However, overexpressing PHO85 did not suppress the temperature sensitive phenotype of the cdc28-1 mutation. The nucleotide sequence of the PHO85 gene strongly suggests the presence of an intron near the sequence encoding the N-terminal region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • CDC2 Protein Kinase
  • Cyclin-Dependent Kinases*
  • DNA, Fungal
  • Fungal Proteins / genetics*
  • Genes, Fungal*
  • Molecular Sequence Data
  • Phosphoproteins / genetics
  • Protein Kinases / genetics*
  • Repressor Proteins / genetics*
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / genetics*


  • DNA, Fungal
  • Fungal Proteins
  • Phosphoproteins
  • Repressor Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • Protein Kinases
  • CDC2 Protein Kinase
  • Cyclin-Dependent Kinases
  • PHO85 protein, S cerevisiae