Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives

Epigenomics. 2019 Feb;11(3):349-362. doi: 10.2217/epi-2018-0081. Epub 2019 Jan 23.


Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative treatment and preventive strategies for cancer. For example, in gastric cancer, cholecalciferol, curcumin, resveratrol, quercetin, garcinol and sodium butyrate are natural regulators of acetylation and deacetylation enzyme activity that exert chemopreventive and anticancer effects. Here, we review the recent findings on histone acetylation in gastric cancer and discuss the effects of nutrients and bioactive compounds on histone acetylation and their potential role in the prevention and treatment of this type of cancer.

Keywords: bioactive compounds; cholecalciferol; curcumin; garcinol; histone acetyltransferase; histone deacetylase; nutrients; nutriepigenetics; quercetin; resveratrol; sodium butyrate.

Publication types

  • Review

MeSH terms

  • Acetylation / drug effects
  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Dietetics
  • Disease Susceptibility*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Histone Deacetylase Inhibitors / pharmacology
  • Histone Deacetylase Inhibitors / therapeutic use
  • Histones / metabolism*
  • Humans
  • Protein Processing, Post-Translational
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy


  • Antineoplastic Agents
  • Histone Deacetylase Inhibitors
  • Histones