Oncogenic KRAS hotspot mutations are rare in IDH-mutant gliomas

Jens Schittenhelm; Nadin Krischker; Irina Gepfner-Tuma; Felix Behling; Susan Noell; Franziska Eckert; Saskia Biskup; Ghazaleh Tabatabai

doi:10.1111/bpa.12709

Oncogenic KRAS hotspot mutations are rare in IDH-mutant gliomas

Brain Pathol. 2019 May;29(3):321-324. doi: 10.1111/bpa.12709. Epub 2019 Feb 1.

Authors

Jens Schittenhelm^{1

2}, Nadin Krischker², Irina Gepfner-Tuma^{1

3}, Felix Behling^{1

4}, Susan Noell^{1

4}, Franziska Eckert^{1

5

6}, Saskia Biskup⁷, Ghazaleh Tabatabai^{1

3

8

6}

Affiliations

¹ Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
² Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
³ Interdisciplinary Division of Neurooncology, Departments of Vascular Neurology & Neurosurgery University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Hertie-Institute for Clinical Brain Research, Tuebingen, Germany.
⁴ Department of Neurosurgery, University Hospital of Tuebingen, Eberhard Karls University Tuebingen, Tuebingen, Germany.
⁵ Department of Radiation Oncology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen, Germany.
⁶ German Consortium for Translational Cancer Research (DKTK), DKFZ partner site Tuebingen, Tuebingen, Germany.
⁷ CeGaT GmbH and Praxis für Humangenetik Tuebingen, Tuebingen, Germany.
⁸ Center for Personalized Medicine, Eberhard Karls University of Tuebingen, Tuebingen, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain Neoplasms / enzymology
Brain Neoplasms / genetics*
Female
Glioma / enzymology
Glioma / genetics*
Glioma / metabolism
Humans
Isocitrate Dehydrogenase / genetics*
Isocitrate Dehydrogenase / metabolism
Male
Middle Aged
Mutation
Proto-Oncogene Proteins p21(ras) / genetics*
Proto-Oncogene Proteins p21(ras) / metabolism

Substances

KRAS protein, human
Isocitrate Dehydrogenase
Proto-Oncogene Proteins p21(ras)