Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Molecules. 2019 Jan 22;24(3):385. doi: 10.3390/molecules24030385.

Abstract

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32⁻128 µg/mL; 0.145⁻0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

Keywords: (E)-8(17),12-labdadiene-15,16-dial; Zingiber monatnum; antimicrobial resistance; methicillin resistant Staphylococcus aureus (MRSA); multi-drug resistant (MDR); terpenes; zerumbol.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Drug Evaluation, Preclinical
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Terpenes / chemistry
  • Terpenes / pharmacology*
  • Zingiberaceae / chemistry*

Substances

  • Anti-Bacterial Agents
  • Plant Extracts
  • Terpenes