Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in STAT2 KO Syrian Hamsters

Viruses. 2019 Jan 22;11(2):92. doi: 10.3390/v11020092.


Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in STAT2 knockout (KO) golden Syrian hamsters both prophylactically and therapeutically. These antibodies also prevent testicular lesions in this hamster model. Our data indicate that antibody-mediated immunotherapy is effective in treating ZIKV infection. Because suitable quantities of highly potent human polyclonal antibodies can be quickly produced from the TcB system against ZIKV and have demonstrated therapeutic efficacy in a small animal model, they have the potential as an effective countermeasure against ZIKV infection.

Keywords: STAT2 KO hamster; Zika virus; testis; therapeutic; transchromosomal bovine antibody.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Antibodies, Neutralizing / immunology
  • Antibodies, Neutralizing / therapeutic use*
  • Antibodies, Viral / immunology
  • Antibodies, Viral / therapeutic use*
  • Cattle
  • Cricetinae
  • Disease Models, Animal
  • Female
  • Gene Knockout Techniques
  • Humans
  • Immunization, Passive*
  • Male
  • STAT2 Transcription Factor / genetics*
  • Testis / pathology
  • Testis / virology
  • Zika Virus
  • Zika Virus Infection / prevention & control*
  • Zika Virus Infection / therapy*


  • Antibodies, Neutralizing
  • Antibodies, Viral
  • STAT2 Transcription Factor