Immunohistochemical localization of glutathione peroxidase in ocular tissue

Curr Eye Res. 1988 Oct;7(10):1023-7. doi: 10.3109/02713688809015149.


In this study enzyme glutathione peroxidase was localized in ocular tissue of Lewis rats using the peroxidase antiperoxidase immunohistochemical technique. Antisera to glutathione peroxidase was raised in a rabbit. Immunoreactive glutathione peroxidase was found to be distributed predominantly in the corneal epithelium and endothelium, choroid, inner segment of photoreceptors and retinal pigmented epithelium. Its presence in these sites suggests an adaptation to oxidative stress where this antioxidant enzyme along with other antioxidant systems serves to prevent damage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Choroid / enzymology
  • Cornea / enzymology
  • Endothelium, Corneal / enzymology
  • Epithelium / enzymology
  • Eye / enzymology*
  • Glutathione Peroxidase / analysis*
  • Immunoenzyme Techniques
  • Photoreceptor Cells / enzymology
  • Pigment Epithelium of Eye / enzymology
  • Rabbits
  • Rats
  • Rats, Inbred Lew
  • Retina / enzymology


  • Glutathione Peroxidase