Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues

Thomas Korn

doi:10.1016/j.cell.2018.12.025

Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues

Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.

Author

Thomas Korn¹

Affiliation

¹ Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: thomas.korn@tum.de.

PMID: 30682369
DOI: 10.1016/j.cell.2018.12.025

Abstract

By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Astrocytes*
Cues*
Inflammation
Zebrafish