Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues

Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.


By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Astrocytes*
  • Cues*
  • Inflammation
  • Zebrafish