Beta-defensins are proinflammatory pruritogens that activate Mrgprs

J Allergy Clin Immunol. 2019 May;143(5):1960-1962.e5. doi: 10.1016/j.jaci.2019.01.013. Epub 2019 Jan 22.

Authors

Li Zhang¹, Benjamin D McNeil²

Affiliations

¹ Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
² Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: benjamin.mcneil@northwestern.edu.

PMID: 30682457
DOI: 10.1016/j.jaci.2019.01.013

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Degranulation
Cell Line
Female
Ganglia, Spinal / physiology
Humans
Male
Mast Cells / physiology*
Mice, Inbred C57BL
Mice, Knockout
Pruritus*
Rats
Receptors, G-Protein-Coupled / genetics
Receptors, G-Protein-Coupled / physiology*
beta-Defensins / physiology*

Substances

Receptors, G-Protein-Coupled
beta-Defensins