[Stimulation of reparative processes in myocardial infarction: comparative evaluation of the effects of piracetam and inosine]

Kardiologiia. 1988 Nov;28(11):46-50.
[Article in Russian]

Abstract

A study of 102 patients with primary macrofocal myocardial infarction, admitted to hospital within the first 6 hours after the onset of the disease, and experimental evidence obtained in 110 Wistar rats are reported. In a control group of myocardial infarction patients, collagen synthesis was depressed in the presence of the activation of free-radical lipid oxidation and circulatory hypoxia. Piracetam and inosine treatment was associated with the inhibition of free-radical lipid oxidation and a reduction of hypoxia, those being accompanied by increased collagenogenesis and accelerated postinfarction scar formation. Piracetam, as compared to inosine, had a more marked stimulating effect on the development of compensatory myocardial hypertrophy, thus contributing to rapid recovery of cardiac contractility and reducing manifestations of circulatory insufficiency.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Animals
  • Clinical Trials as Topic
  • Collagen / metabolism
  • Drug Evaluation, Preclinical
  • Female
  • Free Radicals
  • Humans
  • Hypoxia / drug therapy
  • Hypoxia / etiology
  • Inosine / therapeutic use*
  • Lipid Peroxidation / drug effects
  • Male
  • Middle Aged
  • Myocardial Contraction / drug effects
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / physiopathology
  • Myocardium / metabolism
  • Piracetam / therapeutic use*
  • Pyrrolidinones / therapeutic use*
  • Rats
  • Rats, Inbred Strains
  • Stimulation, Chemical

Substances

  • Free Radicals
  • Pyrrolidinones
  • Inosine
  • Collagen
  • Piracetam