Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review

J Assist Reprod Genet. 2019 Apr;36(4):607-611. doi: 10.1007/s10815-019-01407-y. Epub 2019 Jan 25.


Purpose: The aim of the systematic review is to describe the obstetrical complications associated with pregnancies in the context of a thin endometrial lining.

Methods: Systematic review of the literature.

Results: Patients who conceive in the setting of a thin endometrium have a significantly increased risk of early pregnancy loss, namely miscarriage and ectopic pregnancy. These patients also have a twofold increase in low birth weight and preterm delivery, as well as a significantly higher risk of intrauterine growth restriction and composite adverse perinatal outcomes.

Conclusions: In addition to the lower probability of conception, a thin endometrium in assisted reproductive technologies appears to be associated with both early and late pregnancy complications. These pregnancies thus warrant special attention and close follow-up from obstetricians.

Keywords: Ectopic pregnancy; Low birth weight; Miscarriage; Obstetrical complications; Preterm delivery; Thin endometrium.

Publication types

  • Systematic Review

MeSH terms

  • Adult
  • Embryo Transfer
  • Endometrium / physiopathology*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / physiopathology*
  • Pregnancy Rate
  • Reproductive Techniques, Assisted*
  • Sperm Injections, Intracytoplasmic