Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study

Ocul Surf. 2019 Apr;17(2):278-284. doi: 10.1016/j.jtos.2019.01.005. Epub 2019 Jan 24.


Purpose: To investigate whether social support and social trust are associated with DED.

Methods: Cross-sectional data from the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) were used. Subjects are 96,227 Japanese men and women aged 40 to 74. Data from respondents included information on DED, social support and social trust. DED was defined as the presence of clinically diagnosed DED or severe symptoms. Social support was measured by emotional support and tangible support. Social trust was measured by level of general trust in others. Multiple logistic regression analysis was conducted to assess the association of social determinants for DED.

Results: Individuals with high levels of social support and social trust were less likely to have severe symptoms of DED and clinically diagnosed DED (P for trend < 0.001 in both cases). Those with the highest levels of social support and social trust were least likely to have DED (odds ratios [OR] = 0.64 [0.61-0.67], 95% confidence interval [CI] = 0.63 [0.60-0.67] for severe symptoms of DED; OR = 0.88 [0.83-0.93] and 0.85 [0.80-0.91] for clinically diagnosed DED).

Conclusions: High levels of social support and social trust were associated with a lower prevalence of DED.

Keywords: Dry eye disease; Social support; Social trust.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cross-Sectional Studies
  • Dry Eye Syndromes / epidemiology
  • Dry Eye Syndromes / psychology*
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Risk Factors
  • Social Support*
  • Surveys and Questionnaires
  • Trust*