Objective: To investigate the incidence and related independent risk factors of depression in treatment-naïve Han ethnic Chinese patients with chronic hepatitis C. Methods: Nine hundred and ninety-seven Han Chinese patients with confirmed chronic HCV infection were enrolled. Beck's depression inventory scale was used to assess depression score. Patients were divided into two groups according to the score: score≥17, depression group (16.85%, 168/997); score <17, no depression group (83.15%, 829/997). Multivariate logistic regression was used to analyze independent risk factors related with the onset of depression in patients with chronic hepatitis C. Results: There was a statistically significant difference between the two groups in terms of gender distribution, marital status, education level, income level and smoking status (P < 0.05). Independent risk factors were female [odds ratio (OR) = 3.85; 95% CI: 2.28-6.50, P = 0.001], decompensated cirrhosis [OR = 2.31; 95% CI: 1.20-4.48, P = 0.013], unmarried [OR = 2.01; 95% CI: 1.12-3.60, P = 0.019], separated [OR = 17.39; 95% CI: 1.64-184.47, P = 0.018], divorced [OR = 3.82; 95% CI: 1.36-10.74, P = 0.011], without higher education [OR = 2.04; 95% CI: 1.22-3.42, P = 0.007], low income [OR = 3.94; 95% CI: 1.38-11.28, P = 0.011], middle income [OR = 2.96; 95% CI: 1.02-8.62, P = 0.047], uninterrupted smoking [OR = 3.67; 95% CI: 2.13-6.31, P = 0.001], and previously smoked [OR = 3.33, 95% CI: 1.66-6.68, P = 0.001]. Conclusion: The incidence of depression in patients with chronic hepatitis C is relatively high. The independent risk factors related with depression include female, unmarried, separated, and divorced, without higher education, low and middle-income level, smoking and disease progression to decompensated cirrhosis, but no significant correlation between hepatitis C virus genotypes and viral load.
目的： 了解初治慢性丙型肝炎患者汉族人群中，抑郁症发病率及相关独立危险因素。 方法： 有997例符合入选标准慢性丙型肝炎患者纳入了研究。应用贝克抑郁量表对患者进行抑郁评分。根据得分将患者分为两组：得分≥17，为抑郁症组（占16.85%, 168/997）；得分< 17，无抑郁症组（占83.15%, 829/997）。用多变量logistic回归分析与慢性丙型肝炎患者抑郁症发病相关的独立危险因素。 结果： 两组在性别组成、婚姻状况、受教育水平、收入水平及是否吸烟等方面差异均有统计学意义(P值均< 0.05)。慢性丙型肝炎患者抑郁症发生的独立危险因素：女性[比值比（OR）= 3.85，95%可信区间（CI）：2.28～6.50，P = 0.001]；失代偿期肝硬化[OR = 2.31，95%CI：1.20～4.48，P = 0.013]；单身[OR = 2.01，95%CI：1.12～3.60，P = 0.019]；分居[OR = 17.39，95%CI：1.64～184.47，P = 0.018]；离异[OR = 3.82，95%CI：1.36～10.74，P = 0.011]；未受过高等教育[OR = 2.04，95%CI：1.22～3.42，P = 0.007]；低收入[OR = 3.94，95%CI：1.38～11.28，P = 0.011]；中等收入[OR = 2.96，95%CI：1.02～8.62，P = 0.047]；吸烟[OR = 3.67，95%CI：2.13～6.31，P = 0.001]；及曾经吸烟[OR = 3.33，95%CI：1.66～6.68，P = 0.001]。 结论： 慢性丙型肝炎患者抑郁症发病率相对较高，抑郁症发生相关独立危险因素有女性、单身、分居、离异等婚姻状况、未受过高等教育、低收入水平、吸烟及疾病进展至肝硬化失代偿期，而与丙型肝炎病毒载量及基因型无显著的相关性。.
Keywords: Depressive disorder; Hepatitis C, chronic; Incidence; Risk factors.