Clinical application of epiderm growth factor in patients with most severe eye burns

Ophthalmologica. 1988;197(4):179-84. doi: 10.1159/000309941.


20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burns, Chemical / drug therapy
  • Clinical Trials as Topic
  • Double-Blind Method
  • Epidermal Growth Factor / therapeutic use*
  • Eye Burns / drug therapy*
  • Fibronectins / therapeutic use
  • Humans


  • Fibronectins
  • Epidermal Growth Factor