Soluble interleukin-2 receptors in the serum of patients with chronic renal failure

Tohoku J Exp Med. 1988 Aug;155(4):343-7. doi: 10.1620/tjem.155.343.

Abstract

The levels of soluble form of the interleukin-2 receptor (sIL-2R) were evaluated in the peripheral blood of 29 patients with chronic renal failure (CRF) using enzyme-linked immunosorbent assay. All patients had undergone hemodialysis and the mean (+/- S.D.) BUN was before hemodialysis was 80.9 +/- 22.4 mg/100 ml. The mean level of sIL-2R was 1146 +/- 258 U/ml, which was significantly higher than the level (288 +/- 118 U/ml) in 12 individuals with a normal BUN level (p = 0.01). In patients with CRF, the elevated sIL-2R level was not influenced by hemodialysis, and not correlated with creatinine or beta 2-microglobulin levels. The kidneys may play an important role in the catabolism of serum sIL-2R. The elevated sIL-2R level may be related to compromised immunoregulation in CRF.

MeSH terms

  • Biomarkers / blood*
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-2 / blood*
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / immunology*
  • Receptors, Interleukin-2 / analysis*
  • Reference Values
  • Solubility
  • beta 2-Microglobulin / analysis

Substances

  • Biomarkers
  • Interleukin-2
  • Receptors, Interleukin-2
  • beta 2-Microglobulin
  • Creatinine