Isolation of Nontuberculous Mycobacteria in Southeast Asian and African Human Immunodeficiency Virus-infected Children With Suspected Tuberculosis

Clin Infect Dis. 2019 May 2;68(10):1750-1753. doi: 10.1093/cid/ciy897.

Abstract

We enrolled 427 human immunodeficiency virus-infected children (median age, 7.3 years), 59.2% severely immunodeficient, with suspected tuberculosis in Southeast Asian and African settings. Nontuberculous mycobacteria were isolated in 46 children (10.8%); 45.7% of isolates were Mycobacterium avium complex. Southeast Asian origin, age 5-9 years, and severe immunodeficiency were independently associated with nontuberculous mycobacteria isolation.

Clinical trials registration: NCT01331811.

Keywords: HIV; children; nontuberculous mycobacteria; tuberculosis.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa / epidemiology
  • Asia, Southeastern / epidemiology
  • Child
  • Child, Preschool
  • Clinical Laboratory Techniques
  • HIV
  • HIV Infections / complications*
  • HIV Infections / epidemiology
  • HIV Infections / microbiology
  • Humans
  • Immunologic Deficiency Syndromes / epidemiology*
  • Immunologic Deficiency Syndromes / microbiology
  • Immunologic Deficiency Syndromes / virology
  • Mycobacterium Infections, Nontuberculous / diagnosis*
  • Mycobacterium Infections, Nontuberculous / epidemiology
  • Mycobacterium Infections, Nontuberculous / microbiology
  • Mycobacterium avium Complex / isolation & purification
  • Nontuberculous Mycobacteria / classification
  • Nontuberculous Mycobacteria / isolation & purification*
  • Prospective Studies
  • Tuberculosis / diagnosis
  • Tuberculosis / epidemiology*
  • Tuberculosis / microbiology

Associated data

  • ClinicalTrials.gov/NCT01331811